Carlos J. Gallardo-Dodd

tTEscanR quantifies and visualizes translation efficiency from transcriptomic data across diverse biological systems, revealing translational regulatory programs in cancer, aging, and neurodegeneration.

The paper identifies key RBP regulatory interactions in liver cancer and suggests potential drug candidates through GRN analysis and enrichment studies.

This study shows that activating estrogen receptors in male mice reduces HFD-induced liver steatosis by modulating gene expression and TEAD1, suggesting TEAD1 inhibition as a therapeutic strategy for NAFLD.

The paper analyzes single-cell data to show stable codon and anticodon usage across cell types, with neurons having higher translation efficiency due to increased tRNAAla (AGC) anticodons.

This study identifies Foxm1 as a critical transcription factor for spinal cord regeneration in axolotls by regulating neuronal differentiation rather than proliferation.