Author

Valerio Guido Giacobelli

Czech Academy of SciencesORCID 0000-0002-6086-3671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Klára HlouchováiD· 3 shared Radko SoučekiD· 2 shared Robin KryštůfekiD· 2 shared Václav VerneriD· 2 shared A. Knetl· 1 shared Anton BokaciD· 1 shared Giuliano ZanchettaiD· 1 shared Ingemar AndréiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Klára HlouchováORCID

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3 papers

Recent·Most cited

Protoribosomal condensate formation across cationic chemistries

Simone Codispoti, Valerio Guido Giacobelli, Matúš Friček, Václav Verner, Julie Nováková, Martin Mašek, Anton Bokac, Robin Kryštůfek, Radko Souček, Michal Kolář, Giuliano Zanchetta, Klára Hlouchová

This study compares how different cationic chemistries influence peptide-RNA coacervation, showing that statistical peptide ensembles can drive protoribosomal condensate formation without sequence-specific optimization.

bioRxiv · Oct 1, 2026 · PreprintBiochemistry

Ancient amino acid sets enable stable protein folds

Valerio Guido Giacobelli, S. Andersson, Pavel Srb, Tereza Neuwirthová, Z. Ruszová, J. Marhoul, S. Pšenička, A. Knetl, Lucie Bednářová, Václav Veverka, Klára Hlouchová, Ingemar André

The paper designs ancient proteins using a limited amino acid set and shows they are stable and mutation-resilient.

bioRxiv · Oct 29, 2025 · PreprintBiochemistry

Peptides at vesicle and mineral prebiotic interfaces

Ivan Cherepashuk, Mikhail Makarov, Radko Souček, Václav Verner, Robin Kryštůfek, Romana Hadravová, Valerio Guido Giacobelli, Kosuke Fujishima, Seán F. Jordan, Liam M. Longo, Klára Hlouchová

This study investigates how peptides interact with mineral surfaces and lipid vesicles, showing acidic residues bind minerals and arginine enhances phosphate mobilization, while different amino acid alphabets affect vesicle stability.

bioRxiv · Jun 13, 2025 · PreprintEvolutionary Biology