Microbiota and metabolic adaptation shape Staphylococcus aureus virulence and antimicrobial resistance during intestinal colonization
Chunyi Zhou, Miranda B. Pawline, Alejandro Pironti, Sabrina M. Morales, Andrew I. Perault, Robert J. Ulrich, Magdalena M Podkowik, Alannah Lejeune, Ashley Dumont, François‐Xavier Stubbe, Aryeh Korman, Drew R. Jones, Jonas Schlüter, Anthony R. Richardson, Paul D. Fey, , Bo Shopsin
This study shows that gut microbiota depletion allows MRSA to adapt through genetic changes that enhance colonization fitness but reduce antimicrobial resistance and virulence.
bioRxiv · May 11, 2024 · PreprintMicrobiology