Bo Shopsin

This study shows that collagen binding adhesin (Cna) in Staphylococcus aureus reduces skin infection severity by binding to C1q and limiting inflammation.

This study identifies a prophage-encoded methyltransferase, pamA, that enhances virulence in CA-MRSA by epigenetically upregulating fnbA, promoting biofilm formation and abscess size.

This study identifies the gut as a major reservoir of Staphylococcus aureus that can be transmitted to the skin and worsen atopic dermatitis.

This study shows female mice clear MRSA from the gut faster than males, relying on gut microbiota and Th17 cells, while ovariectomy reduces this resistance.

This study shows that gut microbiota depletion allows MRSA to adapt through genetic changes that enhance colonization fitness but reduce antimicrobial resistance and virulence.

The paper shows that heterozygosity for the ATG16L1 T300A allele protects against Salmonella infection, while homozygosity increases susceptibility.

This study introduces a genome-wide classification of regulatory modes in bacteria by analyzing transcription-replication interactions, revealing new insights into gene expression dynamics and regulatory context.