Author

M.-C. Beauchamp

Research Institute of the McGill University Health CentreORCID 0000-0002-6124-0345Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Loydie Anne Jerome‐MajewskaiD· 3 shared Eric BarekeiD· 2 shared Jacek MajewskiiD· 2 shared Sabrina Shameen AlamiD· 2 shared Aidan R. O’BrieniD· 1 shared Alexia Boucher· 1 shared Amy Gonzales· 1 shared Andrew S. I. LoudoniD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersDevelopmental Biology

Loydie Anne Jerome‐MajewskaORCID

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3 papers

Recent·Most cited

Developmental BiologybioRxivPreprintAug 7, 2021

Snrpb, the CCMS gene, is required in neural crest cells for proper splicing of genes essential for craniofacial morphogenesis

Sabrina Shameen Alam, Shruti Kumar, M.-C. Beauchamp…·Loydie Anne Jerome‐Majewska

This study shows that Snrpb mutations cause craniofacial defects by disrupting splicing of genes involved in P53 regulation and craniofacial development.

DOI 10.1101/2021.08.07.455514

mousebulk RNA-seq

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Developmental BiologybioRxivPreprintSep 22, 2020

Mis-splicing of Mdm2 leads to increased P53-activity and craniofacial defects in a MFDM Eftud2 mutant mouse model

M.-C. Beauchamp, Anissa Djedid, Eric Bareke…·Loydie Anne Jerome‐Majewska

This study shows that EFTUD2 mutations cause mis-splicing of Mdm2, leading to increased P53 activity and craniofacial defects, which can be mitigated by P53 inhibitors.

1 citation

mousebulk RNA-seq

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GeneticsGenome biologyPeer-reviewedAug 25, 2019

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros…·Atsushi Yoshiki

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.

102 citationstop 3%

mousestatistical model

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