CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation
Wyatt D. Miller, Andrew Manion, Abhinava K. Mishra, Connor J. Sheedy, Annalise Bond, Brooke M. Gardner, Denise J. Montell, Meghan A. Morrissey
This study shows CD47 inhibits Rac-mediated phagocytosis by preventing Vav1 phosphorylation, shifting the mechanism from Rac-based reaching to Rho-based sinking.
The Journal of Cell Biology · Sep 18, 2025Peer-reviewedCell Biology