Author

Connor J. Sheedy

University of California, Santa BarbaraORCID 0000-0002-9161-7182Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Brooke M. GardneriD· 3 shared Chris D. RichardsoniD· 2 shared Soham P. ChowdhuryiD· 2 shared Abhinava K. MishraiD· 1 shared Andrew ManioniD· 1 shared Annalise BondiD· 1 shared Bashir A. AliiD· 1 shared Denise J. MontelliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

Brooke M. GardnerORCID

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3 papers

Recent·Most cited

Autophagy dependent HIF1α proteostasis is compromised in models of PEX1 deficiencies

Soham P. Chowdhury, Sambhav Jain, Milagros Esmerode, HENRY DONG, Jonathan T. Vu, Connor J. Sheedy, Chris D. Richardson, Brooke M. Gardner

This study shows that PEX1 deficiencies disrupt HIF1α proteostasis via autophagy, leading to increased HIF1 levels and impaired recovery under hypoxia-reoxygenation.

bioRxiv · Sep 30, 2026 · PreprintCell Biology

CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation

Wyatt D. Miller, Andrew Manion, Abhinava K. Mishra, Connor J. Sheedy, Annalise Bond, Brooke M. Gardner, Denise J. Montell, Meghan A. Morrissey

This study shows CD47 inhibits Rac-mediated phagocytosis by preventing Vav1 phosphorylation, shifting the mechanism from Rac-based reaching to Rho-based sinking.

The Journal of Cell Biology · Sep 18, 2025Peer-reviewedCell Biology

PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome

Connor J. Sheedy, Soham P. Chowdhury, Bashir A. Ali, Julia Miyamoto, Eric Z. Pang, Julien Bacal, Katherine U. Tavasoli, Chris D. Richardson, Brooke M. Gardner

This study shows that the PEX1G843D mutation impairs PEX1/PEX6 assembly and leads to proteasomal degradation, but overexpression can restore peroxisome function.

Journal of Biological Chemistry · Mar 31, 2025Peer-reviewedBiochemistry