Streptococcus pyogenes nuclease A interferes with host complement functions
Isabella Andersson Bennig, Joel Ströbaek, Rafael Mamede, Ariane Neumann, Ana Friães, Mário Ramirez, Michael Hall, Mattias Collin, Lars Malmström, Simon Ekström, Inga-Maria Frick, Lars Björck, Lotta Happonen
This study identifies SpnA's role in inhibiting the complement system by interacting with C5b67, preventing membrane attack complex assembly.
bioRxiv · Aug 25, 2025 · PreprintMicrobiology