Simon Ekström

Structural profiling of the pneumolysin epitope landscape uncovers a cross-species neutralising site across cholesterol-dependent cytolysins

The paper maps the structural epitope landscape of pneumolysin and identifies a conserved cross-species neutralising site among cholesterol-dependent cytolysins.

Regulation of ADP-ribosyltransferase activity by ART domain dimerization in PARP15

This study shows that PARP15's ADP-ribosyltransferase activity is regulated by dimerization, with dimers required for catalytic function and monomers inactive.

Streptococcus pyogenes nuclease A interferes with host complement functions

This study identifies SpnA's role in inhibiting the complement system by interacting with C5b67, preventing membrane attack complex assembly.

Design of a Streptolysin O Epitope-Centric Nanoparticle Vaccine Against Streptococcus pyogenes

This paper designs an epitope-centric nanoparticle vaccine against Streptococcus pyogenes using structural mass spectrometry and deep learning to enhance immunogenicity.

Streptolysin O Accelerates the Conversion of Plasminogen to Plasmin

This study shows that streptolysin O enhances plasminogen to plasmin conversion by interacting with plasminogen and altering its conformation to increase sensitivity to proteolytic processing.