Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via redistriburion of E-cadherin
Yvonne Xinyi Lim, Min Liu, Bailey Fabiny Garb, Allison Kate Cullen Furgal, Shiting Li, Shaomiao Xia, Andrew Whiteman, Junsouk Choi, Qingzhi Liu, Huira C. Kopera, Roland Hilgarth, Marcell Costa de Medeiros, Laura Gonzalez-Maldonado, Thomas M. Lanigan, Jonathan Mchugh, , Nisha J. D’Silva
This study shows that HPV16 E6 splicing variants influence oropharyngeal cancer aggressiveness by altering E-cadherin localization and clinical outcomes.
bioRxiv · Oct 16, 2025 · PreprintCancer Biology