Shiting Li

Rewiring Oncogenic Transcriptional Complexes with Domain-ALTerAtion Chimeras (DALTACs) in Prostate Cancer

A bifunctional AR–p300/CBP molecule, DALTAC-1, forces a non-native contact between AR and p300 domains, silences AR enhancers and regresses AR-driven prostate tumors in mice while sparing AR-negative lines.

TFBSpedia: a comprehensive human and mouse transcription factor binding sites database

The paper constructs a comprehensive TFBS database by integrating multiple resources and evaluates their accuracy using independent datasets.

HPV integration in head and neck cancer: downstream splicing events and expression ratios linked with poor outcomes

This study examines HPV integration in HNSCC using RNA-seq data to link splicing events and expression ratios to poor clinical outcomes.

Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via redistriburion of E-cadherin

This study shows that HPV16 E6 splicing variants influence oropharyngeal cancer aggressiveness by altering E-cadherin localization and clinical outcomes.

Tumor Subtype Classification Tool for HPV-associated Head and Neck Cancers

This paper develops a machine learning classifier to subtype HPV+ HNSCC tumors into IMU or KRT using bulk RNA-seq data and validates its accuracy across multiple cohorts.