Cancer BiologyeLifePeer-reviewed
Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism
Weijie Wu, Miao Yu, Qianchen Li…·Hongquan Zhang
This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.
DOI 10.7554/elife.101888.3