Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism
Weijie Wu, Miao Yu, Qianchen Li, Yiqian Zhao, Lei Zhang, Yi Sun, Zhenbin Wang, Yuqing Gong, Wenjing Wang, Chen‐Ying Liu, Jing Zhang, Yan Tang, Xiaojie Xu, Xiao-Jing Guo, Jun Zhan, Hongquan Zhang
This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.
eLife · Mar 31, 2025Peer-reviewedCancer Biology