Cristina Ruedell Reschke

This study shows inhibiting miR-134 reduces single neuron and network hyperexcitability in mice with drug-resistant temporal lobe epilepsy.

This study shows that epileptogenesis disrupts the circadian clock and alters diurnal transcriptomic rhythms in the mouse hippocampus, with implications for human epilepsy.

The paper identifies brain-originating microRNAs in the blood of mice with experimental epilepsy, supporting their use as biomarkers.

This study shows that deleting miR-155 in myeloid cells reduces seizure severity and inflammation in a neonatal hypoxia-induced seizures model.

This study investigates sex differences and long-term comorbidities in Scn1a(+/-)tm1Kea mice modeling Dravet Syndrome, finding sex-specific seizure patterns and reduced behavioral impairments in older mice.

This study shows that systemic delivery of Ant-134, timed with BBB disruption after status epilepticus, suppresses seizures in mice with long-lasting effects.

The paper identifies functional miRNAs and their targets involved in seizure suppression in temporal lobe epilepsy using animal models and functional screens.