Marina K. M. Alvim

Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study

This study examines sex differences in structural brain alterations in common epilepsies using neuroimaging data from a large international cohort, finding some regional differences but no significant sex-by-diagnosis interactions.

Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomics

This study uses single-nucleus multiomics to map cell types and molecular changes in MOGHE lesions, identifying disease-specific oligodendrocytes and heterotopic neurons with altered gene expression.

Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia

This study uses multi-omics single-cell profiling to identify chromatin and transcriptomic changes in FCD type II, revealing altered cell states and neuronal vulnerability.

EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUS

This study shows that epileptogenesis disrupts the circadian clock and alters diurnal transcriptomic rhythms in the mouse hippocampus, with implications for human epilepsy.

A worldwide ENIGMA study on epilepsy-related gray and white matter compromise across the adult lifespan

This study examines age-related changes in grey and white matter in TLE patients across the adult lifespan, finding accelerated aging effects after age 55.

Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study

This study identifies subregional cerebellar atrophy patterns in epilepsy syndromes using MRI data from 1,602 patients and 1,022 controls, finding significant volume loss in posterior lobe regions.

Identifying cellular markers of focal cortical dysplasia type II with cell-type deconvolution and single-cell signatures

This study uses cell-type deconvolution and single-cell signatures to analyze bulk RNA-seq data from FCD patients, revealing subtype-specific cellular changes, including astrogliosis in FCD IIb.

Topographic divergence of atypical cortical asymmetry and regional atrophy patterns in temporal lobe epilepsy: a worldwide enigma study

This study identifies divergent patterns of atypical cortical asymmetry and regional atrophy in temporal lobe epilepsy using MRI data from a large multi-site cohort.

A systems-level analysis highlights microglial activation as a modifying factor in common forms of human epilepsy

The paper identifies microglial activation as a factor contributing to cortical thinning in epilepsy by integrating neuroimaging and gene expression data.

White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA Epilepsy study

This study identifies white matter microstructural differences across epilepsy syndromes using diffusion MRI data from a large multicenter cohort.