Author

Holly A. Rutherford

University of SheffieldORCID 0000-0002-6227-0271Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:zebrafish· 2

Frequent Co-Authors

Noémie HamiltoniD· 2 shared Stephen A. RenshawiD· 2 shared Christopher James Arthur DuncaniD· 1 shared Diogo CandeiasiD· 1 shared Hannah M. IslesiD· 1 shared Jessica J. PettsiD· 1 shared Jutta GärtneriD· 1 shared Marco HennekeiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Noémie HamiltonORCID

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2 papers

Recent·Most cited

Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model

Holly A. Rutherford, Diogo Candeias, Christopher James Arthur Duncan, Stephen A. Renshaw, Noémie Hamilton

This study shows that macrophage transplantation rescues RNASET2-deficient leukodystrophy in zebrafish by replacing dysfunctional microglia, reducing neuroinflammation and restoring motor function.

Proceedings of the National Academy of Sciences · May 16, 2024Peer-reviewedNeuroscience

Failure to clear developmental apoptosis contributes to the pathology of RNASET2-deficient leukoencephalopathy.

Noémie Hamilton, Holly A. Rutherford, Hannah M. Isles, Jessica J. Petts, Thomas Weber, Marco Henneke, Jutta Gärtner, Mark Dunning, Stephen A. Renshaw

This study identifies dysfunctional microglia in a zebrafish model of RNASET2-deficient leukoencephalopathy as a key contributor to pathological apoptosis and behavioral defects.

bioRxiv · Sep 12, 2019 · PreprintNeuroscience