Noémie Hamilton

Biallelic IRAK4 Variants Associated with Severe Neurological Autoinflammation: An Expansion of the Clinical Phenotype

The paper identifies six patients with biallelic IRAK4 variants causing severe neurological autoinflammation without immunodeficiency, expanding the known phenotype of IRAK4-related disease.

Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model

This study shows that macrophage transplantation rescues RNASET2-deficient leukodystrophy in zebrafish by replacing dysfunctional microglia, reducing neuroinflammation and restoring motor function.

Longitudinal brain studies in adult zebrafish by MRI

This paper introduces a method to image adult zebrafish brains using MRI for longitudinal studies, including a 3D-printed life support chamber and optimized contrast agent delivery.

The effect of absent blood flow on the zebrafish cerebral and trunk vasculature

This study quantifies how absent blood flow affects vascular development in zebrafish cerebral and trunk vasculature, finding more severe effects in the brain.

Failure to clear developmental apoptosis contributes to the pathology of RNASET2-deficient leukoencephalopathy.

This study identifies dysfunctional microglia in a zebrafish model of RNASET2-deficient leukoencephalopathy as a key contributor to pathological apoptosis and behavioral defects.