A role for heavy chain-modification in protecting hyaluronan from free radical fragmentation during inflammation
Suruchi Poddar, Dorothea A. Erxleben, Rebecca J. Dodd, Heidi L. Reesink, Dixy E. Green, Paul L. DeAngelis, Anthony J. Day, Adam R. Hall
This study shows that covalent attachment of heavy chains to hyaluronan protects it from ROS-induced fragmentation during inflammation.
Proceedings of the National Academy of Sciences · Sep 28, 2026Peer-reviewedMolecular Biology