Heidi L. Reesink

This study shows that covalent attachment of heavy chains to hyaluronan protects it from ROS-induced fragmentation during inflammation.

A combinatorial gene therapy targeting inflammation and chondrocyte health slows OA progression and reduces pain in murine and equine models.

This study compares the ability of collagen type II and I to form synovial fluid films and retain lubricin, revealing differences in their functional roles in joint mechanics.

This study uses lectin microarrays and machine learning to identify conserved and species-specific glycan signatures in synovial fluid that distinguish healthy from osteoarthritic joints in humans, dogs, and horses.

This study shows that a single delayed injection of recombinant human lubricin improves cartilage repair tissue quality and lubrication in a rabbit osteochondral defect model.

This study develops recombinant lubricin analogs with improved biocompatibility and lubricating properties, demonstrating their tissue binding and joint retention in rats.