Paweł Czyż

This study shows ecDNA replicates asynchronously and is vulnerable to replication stress, leading to its depletion in cancer cells.

The paper develops a Bayesian framework to model mutual exclusivity in cancer mutations, finding potential mutual exclusivity between EGFR and IDH1 in glioblastoma multiforme.

CanSig benchmarks methods for identifying transcriptional signatures in cancer using scRNA-seq data, finding BBKNN as a leading method with clinically relevant outcomes.

The paper shows that the MAPK/ERK pathway can transmit up to 1.86 bits of information per hour by encoding temporal patterns of EGF pulses into ERK activity pulses.