Pauline Luise Pfuderer

The paper introduces ORILINX, a genome language model that predicts replication origins in human and other mammalian genomes using sequence context.

This study shows ecDNA replicates asynchronously and is vulnerable to replication stress, leading to its depletion in cancer cells.

This study identifies that high levels of DNA replication initiation factors correlate with ATR inhibitor sensitivity due to excessive origin firing in cancer cells.