Gianluca Petris

The paper detects early ERAD initiation events using a BAP-BirA system and shows substrates engage retrotranslocation machinery while remaining membrane-associated.

This study shows ecDNA replicates asynchronously and is vulnerable to replication stress, leading to its depletion in cancer cells.

This study uses CRISPR base editing to introduce revertant mutations in F508del-CFTR, rescuing protein folding and function in CF patient-derived cells.