Julian E. Sale

This study maps DNA supercoiling and chromatin interactions during human stem cell differentiation, showing that gene activation increases negative supercoiling and correlates with enhanced DNA contacts.

The paper introduces ORILINX, a genome language model that predicts replication origins in human and other mammalian genomes using sequence context.

This study shows ecDNA replicates asynchronously and is vulnerable to replication stress, leading to its depletion in cancer cells.

This study shows that DNA replication initiation sites drive mutagenesis and genomic rearrangements in cancers by affecting repair processes and mutational patterns.

The paper maps human DNA replication origins and their efficiency, showing hierarchical organization within initiation zones.

This study shows that replication origins in humans increase mutation rates and influence gene expression and mRNA isoform usage through mutagenic processes during DNA replication.

The paper identifies a G quadruplex binding domain in Timeless and shows its collaboration with DDX11 to process G4 structures during DNA replication.

The paper shows that PrimPol-mediated repriming limits R-loop formation during S phase, preventing replication blocks at susceptible sequences.