Phosphodiesterase 3A modulators sensitize tumor cells to Bcl-xL and Bcl-2/Bcl-xL inhibitors
Kirsi Toivanen, Astrid Murumägi, Agnieszka Woźniak, Karo Wyns, Chao‐Chi Wang, Luna De Sutter, Mariliina Arjama, Nanna Merikoski, Sami Salmikangas, Omar Youssef, Jorma J Isola, Olli Kallioniemi, Patrick Schöffski, Tom Böhling, Harri J. Sihto
This study identifies PDE3A modulators that synergize with Bcl-xL and Bcl-2/Bcl-xL inhibitors to induce tumor regression in sarcoma models.
bioRxiv · Apr 10, 2025 · PreprintMolecular Biology