NeurosciencebioRxivPreprint
Striatal seeding of protofibrillar alpha-synuclein causes cortical hyperreactivity in behaving mice
Sonja Blumenstock, Fanfan Sun, Petar Marinković…·Jochen Wolfgang Herms
This study shows that injecting alpha-synuclein fibrils into the striatum of mice leads to altered cortical neuron function and reduced inhibitory cells in the somatosensory cortex.