Author

Christopher M. Thompson

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-6284-1919Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Aman SharmaiD· 1 shared Carl L. Schildkraut· 1 shared Helen E. GrimsleyiD· 1 shared Manisha JalaniD· 1 shared Sana Ahmed‐Seghir· 1 shared Settapong T Kosiyatrakul· 1 shared Shyam TwayanaiD· 1 shared Simon N. PowelliD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperMolecular Biology

Aman SharmaORCID

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1 paper

Recent·Most cited

A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

Sana Ahmed‐Seghir, Manisha Jalan, Helen E. Grimsley, Aman Sharma, Shyam Twayana, Settapong T Kosiyatrakul, Christopher M. Thompson, Carl L. Schildkraut, Simon N. Powell

The paper shows that a single replication fork barrier activates a local ATR-dependent checkpoint response in human cells, leading to localized DNA damage signaling without affecting global replication.

bioRxiv · Mar 26, 2023 · PreprintMolecular Biology