Simon N. Powell

The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer

The paper identifies the 9-1-1 complex as essential for stabilizing ssDNA gaps in BRCA2-deficient cells through an ATR-independent mechanism, highlighting its role in preventing pathological expansion and DNA damage.

APOBEC3 mutagenesis drives therapy resistance in breast cancer

This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.

RNA Transcripts Serve as a Template for Double-Strand Break Repair in Human Cells

This study demonstrates that RNA transcripts can serve as templates for double-strand break repair in human cells, identifying DNA polymerase-zeta as a key enzyme and revealing genomic scars associated with this process.

A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

The paper shows that a single replication fork barrier activates a local ATR-dependent checkpoint response in human cells, leading to localized DNA damage signaling without affecting global replication.

Novel patterns of complex structural variation revealed across thousands of cancer genome graphs

The paper identifies three novel complex structural variation patterns in cancer genomes using genome graph analysis across 2,833 tumor WGS.