Author

Mohammad Owais Ansari

University of Illinois ChicagoORCID 0000-0002-6285-2909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Asrar B. MalikiD· 2 shared Chinnaswamy TiruppathìiD· 2 shared Dongmei WangiD· 1 shared Gary C. H. MoiD· 1 shared Hui Chen· 1 shared Juan YangiD· 1 shared Lasanthi Jayathilaka· 1 shared Mark Maienschein‐ClineiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Asrar B. MalikORCID

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2 papers

Recent·Most cited

Ubiquitin ligase CHFR impairs Tie2 signaling via K48-linked ubiquitylation and degradation of Akt1 in endothelial cells

Mohammad Owais Ansari, Gary C. H. Mo, Lasanthi Jayathilaka, Hui Chen, Asrar B. Malik, Chinnaswamy Tiruppathì

This study identifies CHFR as a regulator of endothelial inflammatory responses by promoting Akt1 ubiquitylation and degradation, thereby impairing Tie2 signaling and endothelial barrier integrity.

bioRxiv · Mar 31, 2026 · PreprintCell Biology

CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity

Dongmei Wang, Juan Yang, Mohammad Owais Ansari, Zarema H. Arbieva, Mark Maienschein‐Cline, Viswanathan Natarajan, Asrar B. Malik, Chinnaswamy Tiruppathì

This study shows that CaMKKβ regulates Elf2 gene methylation, which is essential for maintaining endothelial barrier integrity by controlling Tie2 and VE-cadherin expression.

iScience · Nov 28, 2025Peer-reviewedCell Biology