Two-step voltage-sensor activation of the human KV7.4 channel and effect of a deafness-associated mutation
Mario Nappi, Damon J.A. Frampton, Ali Saad Kusay, Kaiqian Wang, Sumeyye Suheda Yasarbas, Serena Pozzi, Francesco Miceli, Sara I. Liin, Maurizio Taglialatela, Antonios Pantazis
This study investigates the two-step voltage-sensor activation mechanism of the KV7.4 channel and shows how a deafness mutation disrupts this process.
Nature Communications · Feb 5, 2026Peer-reviewedBiophysics