Jaquette Liljencrantz

This study investigates the effect of blocking Aβ fibers on pain perception and nociceptive withdrawal reflexes in humans, finding that Aβ fibers may contribute to pain and reflex signaling.

The paper identifies PIEZO2-dependent mechanical pain in humans and mice, showing hair-pull pain is mediated by Aβ inputs and specific nociceptors.

The paper shows that A-fiber function is critical for perceiving the pleasantness of gentle stroking and deep pressure in humans.