The paper uses WGCNA to identify protein modules in 1-year-old children linked to respiratory diseases by age 6, showing associations with environmental and metabolomic factors.

Journal of Allergy and Clinical Immunology · Jul 1, 2025Peer-reviewedBioinformatics

The metabolic role of vitamin D in children's neurodevelopment: a network study

Margherita De Marzio, Jessica Ann Lasky-Su, Su H. Chu, Nicole Prince, Augusto A. Litonjua, Scott T. Weiss, Rachel S. Kelly, Kimberly Glass

This study investigates the metabolic role of vitamin D in children's neurodevelopment using a network approach, finding associations between vitamin D deficiency and changes in tryptophan, linoleic, and fatty acid metabolism linked to ASD-related phenotypes.

Scientific Reports · Jul 23, 2024Peer-reviewedSystems Biology

OMICmAge: An integrative multi-omics approach to quantify biological age with electronic medical records

Qingwen Chen, Varun Bhamidipati Dwaraka, Natàlia Carreras-Gallo, Kevin M. Mendez, Yulu Chen, Sofina Begum, Priyadarshini Kachroo, Nicole Prince, Hannah Went, Tavis L. Mendez, Aaron Lin, Logan Turner, Mahdi Moqri, Su H. Chu, Rachel S. Kelly, , Jessica Ann Lasky-Su

The paper develops OMICmAge, a multi-omics biomarker of biological age, and shows it outperforms existing markers in predicting chronic diseases and mortality.

bioRxiv · Oct 16, 2023 · PreprintBioinformatics

Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap

Catherine John, Anna L. Guyatt, Nick R. G. Shrine, Richard J. Packer, Thorunn Asta Olafsdottir, Jiangyuan Liu, Lystra P. Hayden, Su H. Chu, Jukka T. Koskela, Jian’an Luan, Xingnan Li, Natalie Terzikhan, Hanfei Xu, Traci M. Bartz, Hans V. Petersen, , Martin D. Tobin

This study identifies eight novel genetic signals associated with asthma-COPD overlap through a genome-wide association analysis involving multiple cohorts.

CHEST Journal · Jan 31, 2022Peer-reviewedGenetic & Genomic Medicine