Author

Jonathan D. Macdonald

Cleveland ClinicORCID 0000-0002-6360-2768Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:deep learning· 1

Frequent Co-Authors

A. Abigail Lindsey· 1 shared A.M. EdwardsiD· 1 shared Albina Bolotokova· 1 shared Amit Kumar GuptaiD· 1 shared Annabella Rico· 1 shared Anthony R. SloaniD· 1 shared C.H. ArrowsmithiD· 1 shared Christopher G. HubertiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Abigail Lindsey

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Cancer BiologyJCI InsightPeer-reviewedMay 5, 2026

Development and Characterization of Triazole-Based WDR5 Inhibitors for the Treatment of Glioblastoma

Jesse A. Coker, Steven R. Martinez, Sang Hoon Han…·Shaun R. Stauffer

This study develops triazole-based WDR5 inhibitors that show improved brain penetration and antiproliferative activity against glioblastoma CSCs, with synergistic effects when combined with ATAD2 inhibitors.

DOI 10.1172/jci.insight.198298

humanproteomics

Pharmacology & ToxicologybioRxivPreprintNov 21, 2025

Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex

Rocher Leung, Esther Wolf, Justin C. Deme…·Rachel Harding

The paper identifies a small molecule ligand for the HTT-HAP40 complex using AS-MS and validates its binding through multiple techniques, highlighting a druggable interface for HD therapeutics.

DOI 10.1101/2025.11.21.689733

humanproteomics