Esther Wolf

The paper shows that BAY-805 induces USP21-KLHL12 association, recruiting USP21 to COPII vesicles and impairing large cargo transport.

The paper develops macrocyclic peptides that target HAP40, enabling the study of HTT-HAP40 interactions and their role in Huntington's disease.

The paper identifies a small molecule ligand for the HTT-HAP40 complex using AS-MS and validates its binding through multiple techniques, highlighting a druggable interface for HD therapeutics.

This paper identifies and characterizes high-affinity, selective macrocyclic peptide ligands for Huntingtin, enabling structural and functional studies of HTT and its complex with HAP40.

This paper shows that the antibody ICO-hu104 neutralizes SARS-CoV-2 by causing allosteric changes in the HR1 domain, leading to destabilization of helices and impairing viral fusion.

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

This study uses hydrogen deuterium exchange mass spectrometry to show that Mcl-1's binding specificity arises from dynamic modes in its unbound state, distinct from Bcl-2.