Author

Rocher Leung

Structural Genomics ConsortiumORCID 0009-0004-3549-2065Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A.M. EdwardsiD· 2 shared Derek J. WilsoniD· 2 shared Esther WolfiD· 2 shared Rachel J. HardingiD· 2 shared Renu ChandrasekaraniD· 2 shared Suzanne Z. AcklooiD· 2 shared Albina Bolotokova· 1 shared Brandon A. Keith· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

A.M. EdwardsORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Macrocyclic Peptide Tools for Huntingtin-bound HAP40

Esther Wolf, Rebeka Cataldo de Oliveira Fanti, Tatsuya Ikenoue, Rocher Leung, Renu Chandrasekaran, Matthew G. Alteen, Brandon A. Keith, Suzanne Z. Ackloo, A.M. Edwards, Derek Wilson, Hiroaki Suga, Rachel J. Harding

The paper develops macrocyclic peptides that target HAP40, enabling the study of HTT-HAP40 interactions and their role in Huntington's disease.

bioRxiv · Jun 2, 2026 · PreprintMolecular Biology

Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 Complex

Rocher Leung, Esther Wolf, Justin C. Deme, Swati Balakrishnan, Conrad Veranso Simoben, Shulu Feng, Jonathan D. Macdonald, Renu Chandrasekaran, Jianxian Sun, Xiaoyun Wang, Albina Bolotokova, Yefen Zou, Ram Kannan, Suzanne Z. Ackloo, Derek J. Wilson, , Rachel Harding

The paper identifies a small molecule ligand for the HTT-HAP40 complex using AS-MS and validates its binding through multiple techniques, highlighting a druggable interface for HD therapeutics.

bioRxiv · Nov 21, 2025 · PreprintPharmacology & Toxicology