Justin C. Deme

This study shows seipin undergoes conformational changes at the ER-LD interface, enabling lipid droplet growth and regulated lipid storage.

The paper presents cryo-EM structures of the bacterial flagellar Export Apparatus, revealing a rotary gating mechanism coupling proton flow to export channel opening.

The paper reports the cryoEM structure of TraT, an outer membrane protein involved in plasmid exclusion, and suggests it functions by physical interference rather than specific protein interactions.

The paper identifies a small molecule ligand for the HTT-HAP40 complex using AS-MS and validates its binding through multiple techniques, highlighting a druggable interface for HD therapeutics.

The paper investigates how PI(3,5)P2 regulates lysosomal pH by inhibiting ClC-7, showing structural changes in ClC-7 upon PI(3,5)P2 binding and linking this to disease mutations.

The paper presents structures of the Tat core complex in resting and substrate-bound states, revealing how substrate proteins interact with the complex through their signal peptides and proposing a model for early transport steps.

This paper identifies and characterizes high-affinity, selective macrocyclic peptide ligands for Huntingtin, enabling structural and functional studies of HTT and its complex with HAP40.

The paper identifies two distinct immunity protein families that neutralize a bacterial toxin from different compartments.

The paper identifies a shared mechanism between Bacteroidota gliding motility and T9SS protein transport involving disulfide-bonded outer membrane proteins.

This study reports the cryoEM structure of a BAM complex from Flavobacterium johnsoniae, revealing a novel structural paradigm for outer membrane protein biogenesis in Bacteroidota.

The paper identifies SLC45A4 as a pain-related gene encoding a neuronal polyamine transporter through GWAS and functional studies.