Author

Julien Couture‐Senécal

University of TorontoORCID 0000-0002-6370-5839Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Grayson TilstraiD· 2 shared Omar F. KhaniD· 2 shared Alanna M. ManningiD· 1 shared Ana-Maria OproescuiD· 1 shared Atul Humar· 1 shared Janice PangiD· 1 shared Karlene L. M. KnaggsiD· 1 shared Meng Qi JiangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

Grayson TilstraORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The Clearance of Human Cytomegalovirus Using CRISPR/Cas9 RNA Lipid Nanoparticles

Yan Ming Anson Lau, Janice Pang, Meng Qi Jiang, Yikai Sun, Karlene L. M. Knaggs, Grayson Tilstra, Ana-Maria Oproescu, Julien Couture‐Senécal, Alanna M. Manning, Ranim Maaieh, Victor H. Ferreira, Atul Humar, Omar F. Khan

This study develops CRISPR/Cas9 RNA lipid nanoparticles to clear HCMV infections, showing high efficacy and broad strain coverage.

bioRxiv · Dec 17, 2025 · PreprintBioengineering

Engineering ionizable lipids for rapid biodegradation balances mRNA vaccine efficacy and tolerability

Julien Couture‐Senécal, Grayson Tilstra, Omar F. Khan

This study designs and tests biodegradable ionizable lipids for mRNA vaccines, showing they balance efficacy and tolerability by reducing inflammation while maintaining strong immune responses.

bioRxiv · Aug 2, 2024 · PreprintBioengineering