Author

Ana-Maria Oproescu

University of TorontoORCID 0000-0002-1108-1702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Carol Janine SchuurmansiD· 3 shared Dawn L. Zinyk· 3 shared Hussein GhazaleiD· 3 shared Lakshmy VasaniD· 3 shared Satoshi OkawaiD· 3 shared Sisu Han· 3 shared Alexandra MoffatiD· 2 shared Antonio del SoliD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersDevelopmental Biology

Carol Janine SchuurmansORCID

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Author profile →

4 papers

Recent·Most cited

The Clearance of Human Cytomegalovirus Using CRISPR/Cas9 RNA Lipid Nanoparticles

Yan Ming Anson Lau, Janice Pang, Meng Qi Jiang, Yikai Sun, Karlene L. M. Knaggs, Grayson Tilstra, Ana-Maria Oproescu, Julien Couture‐Senécal, Alanna M. Manning, Ranim Maaieh, Victor H. Ferreira, Atul Humar, Omar F. Khan

This study develops CRISPR/Cas9 RNA lipid nanoparticles to clear HCMV infections, showing high efficacy and broad strain coverage.

bioRxiv · Dec 17, 2025 · PreprintBioengineering

NEUROG2 regulates a human-specific neurodevelopmental gene regulatory program

Lakshmy Vasan, Vorapin Chinchalongporn, Fermisk Saleh, Dawn L. Zinyk, Cao Ke, Hamsini Suresh, Hussein Ghazale, Lauren Belfiore, Yacine Touahri, Ana-Maria Oproescu, Shruti B Patel, Matthew W Rozak, Yutaka Amemiya, Sisu Han, Alexandra Moffat, , Carol Janine Schuurmans

The paper identifies NEUROG2's role in regulating a human-specific gene regulatory program in neural progenitor cells through transcriptomic analysis of knock-in organoids.

Development · Dec 16, 2024Peer-reviewedDevelopmental Biology

Proneural genes form a combinatorial code to diversify neocortical neural progenitor cells

Alexandra Moffat, Ana-Maria Oproescu, Satoshi Okawa, Sisu Han, Lakshmy Vasan, Hussein Ghazale, Daniel J. Dennis, Dawn L. Zinyk, François Guillemot, Antonio del Sol, Carol Janine Schuurmans

The paper identifies a proneural gene combinatorial code that diversifies neocortical neural progenitor cells through gene regulatory networks and cell fate decisions.

bioRxiv · Jul 29, 2023 · PreprintDevelopmental Biology

Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding

Sisu Han, Satoshi Okawa, Grey Wilkinson, Hussein Ghazale, Lata Adnani, Rajiv Dixit, Lígia Tavares, Imrul Faisal, Matthew J. Brooks, Véronique Cortay, Dawn L. Zinyk, Adam Sivitilli, Saiqun Li, Faizan Malik, Yaroslav Ilnytskyy, , Carol Janine Schuurmans

The paper shows Neurog2 and Ascl1 genes regulate cortical progenitor differentiation and folding through Notch signaling in lissencephalic brains.

Neuron · Aug 17, 2021Peer-reviewedDevelopmental Biology