A highly conserved sRNA downregulates multiple genes, including a sigma54 transcriptional activator, in the virulence mode of Bordetella pertussis
Minji Sim, Jeffers Nguyen, Karolína Škopová, Kyungyoon Yoo, Chin‐Hsien Tai, Leslie Knipling, Qing Chen, David Dongkyung Kim, Summer Nolan, Rawan A. Elaksher, Nadim Majdalani, Hernán Lorenzi, Scott Stibitz, Kyung Duk Moon, Deborah M. Hinton
This paper identifies an sRNA, S17S, that downregulates multiple genes, including a sigma54 transcriptional activator, in the virulence mode of B. pertussis through complementary base pairing with ribosome binding sites.
mBio · Jul 8, 2025Peer-reviewedMicrobiology