Author

Paolo Rossetti

Friedrich-Alexander-Universität Erlangen-NürnbergORCID 0000-0002-6385-3794Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Marius F.W. TrollmanniD· 2 shared Rainer A. BöckmanniD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersBiophysics

Marius F.W. TrollmannORCID

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2 papers

Recent·Most cited

BiophysicsBiophysical JournalPeer-reviewedJun 26, 2026

Membrane Environment Sets the Functional pKa of Ionizable Lipids

Marius F.W. Trollmann, Paolo Rossetti, Rainer A. Böckmann

This study uses molecular dynamics simulations to show that membrane composition significantly affects the pKa of aminolipids in lipid nanoparticles, influencing their pH-dependent behavior and membrane remodeling.

2 citations

biophysical modelingchromatin & epigenetic regulation

𝕏 PostBluesky

BiophysicsbioRxivPreprintDec 6, 2024

Constant-pH MD Simulations of Lipids

Marius F.W. Trollmann, Paolo Rossetti, Rainer A. Böckmann

This paper applies constant-pH MD simulations to study pH-dependent behavior of cationic ionizable lipids in lipid nanoparticles, focusing on their apparent pKa and implications for drug delivery.

4 citations

mechanistic / dynamical modelprotein folding & dynamics

𝕏 PostBluesky