Marius F.W. Trollmann

Large phospholipid-number asymmetry is not required to reproduce plasma membrane physical properties

The paper uses simulations to show that lipid-type asymmetry, not phospholipid-number imbalance, is sufficient to reproduce key physical properties of plasma membranes.

Membrane Environment Sets the Functional pKa of Ionizable Lipids

This study uses molecular dynamics simulations to show that membrane composition significantly affects the pKa of aminolipids in lipid nanoparticles, influencing their pH-dependent behavior and membrane remodeling.

Decoding pH-Driven Phase Transition of Lipid Nanoparticles

This study uses CpHMD simulations to analyze pH-driven phase transitions in lipid nanoparticles, revealing how pKa shifts affect structure and mRNA delivery.

Bottom-up investigation of spatiotemporal glycocalyx dynamics with interferometric scattering microscopy

The paper investigates glycocalyx dynamics using interferometric scattering microscopy and finds a strong correlation between glycan structure and system dynamics.

Constant-pH MD Simulations of Lipids

This paper applies constant-pH MD simulations to study pH-dependent behavior of cationic ionizable lipids in lipid nanoparticles, focusing on their apparent pKa and implications for drug delivery.