Developmental BiologyInternational Journal of Oral SciencePeer-reviewed
The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development
Sebastian Gehlen-Breitbach, Theresa Schmid, Franziska Fröb…·Lina Gölz
This study shows that inactivation of Tip60/Ep400 chromatin remodeling complex subunits Kat5 and Ep400 in mouse cranial neural crest cells disrupts metabolism, proliferation, and facial development, linking KAT5 mutations to orofacial clefting.
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