Matthias Weider

The paper shows hypoxia impairs differentiation of cranial neural crest cells into chondrocytes, osteoblasts, and smooth muscle cells, linking it to orofacial cleft risk.

This study shows that inactivation of Tip60/Ep400 chromatin remodeling complex subunits Kat5 and Ep400 in mouse cranial neural crest cells disrupts metabolism, proliferation, and facial development, linking KAT5 mutations to orofacial clefting.