Michael Wegner

microRNAs control temporal patterning of the vertebrate nervous system

This study shows that microRNAs, specifically let-7 and miR-9 families, regulate the timing of neuronal identity transitions in the developing vertebrate nervous system by controlling temporal transcription factors.

Hypoxia impedes differentiation of cranial neural crest cells into derivatives relevant for craniofacial development

The paper shows hypoxia impairs differentiation of cranial neural crest cells into chondrocytes, osteoblasts, and smooth muscle cells, linking it to orofacial cleft risk.

The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development

This study shows that inactivation of Tip60/Ep400 chromatin remodeling complex subunits Kat5 and Ep400 in mouse cranial neural crest cells disrupts metabolism, proliferation, and facial development, linking KAT5 mutations to orofacial clefting.

scRNA-Sequencing uncovers a TCF-4-dependent transcription factor network regulating commissure development

The paper identifies a TCF-4-dependent transcription factor network regulating commissure development in mice using scRNA-seq and bioinformatic analysis.

Deciphering the Regulatory Landscape of γδ T Cell Development by Single-Cell RNA-Sequencing

This study uses single-cell RNA-sequencing to uncover the developmental trajectory of γδ T cells, identifying c-MAF as a key regulator of IL-17-producing γδ T cell differentiation.