This paper analyzes the evolutionary dynamics of FoxQ2 transcription factors across metazoans, identifying three ancient paralogs and revealing conserved and novel expression patterns in chordates.

bioRxiv · Apr 23, 2025 · PreprintEvolutionary Biology

Tracking Early Mammalian Organogenesis - Prediction and Validation of Differentiation Trajectories at Whole Organism Scale

Iván Imaz-Rosshandler, Christina Rode, Carolina Guibentif, Luke T. G. Harland, Mai-Linh Nu Ton, Parashar Dhapola, Daniel Keitley, Ricard Argelaguet, Fernando J. Calero‐Nieto, Jennifer Nichols, John C. Marioni, Marella F. T. R. De Bruijn, Berthold Göttgens

The paper uses scRNA-Seq and computational methods to predict and validate differentiation trajectories during early mammalian organogenesis, showing agreement between computational predictions and experimental outcomes.

Development · Nov 20, 2023Peer-reviewedDevelopmental Biology

Rabbit Development as a Model for Single Cell Comparative Genomics

Mai-Linh Nu Ton, Daniel Keitley, Bart Theeuwes, Carolina Guibentif, Jonas Ahnfelt‐Rønne, Thomas Kjærgaard Andreassen, Fernando J. Calero‐Nieto, Iván Imaz-Rosshandler, Blanca Pijuan-Sala, Jennifer Nichols, Èlia Benito‐Gutiérrez, John C. Marioni, Berthold Göttgens

This study constructs a rabbit developmental atlas and compares it with mouse data to identify species-specific differences in gene regulation and extra-embryonic tissues.

Nature Cell Biology · Jun 15, 2023Peer-reviewedDevelopmental Biology