Iván Imaz-Rosshandler

Calcium dynamics tune timing of developmental transitions to generate evolutionarily divergent axon tract lengths

The paper shows that slower axon growth in humans, driven by reduced calcium influx, leads to longer axon tracts through prolonged growth duration, with calcium dynamics regulating developmental timing.

Tracking Early Mammalian Organogenesis - Prediction and Validation of Differentiation Trajectories at Whole Organism Scale

The paper uses scRNA-Seq and computational methods to predict and validate differentiation trajectories during early mammalian organogenesis, showing agreement between computational predictions and experimental outcomes.

Bespoke single cell molecular and tissue-scale analysis reveals mechanisms underpinning development and disease in complex developing cell populations

The paper develops statistical tools to analyze gene knockouts in mouse embryos and applies them to study developmental disruptions and cancer therapy responses.

Rabbit Development as a Model for Single Cell Comparative Genomics

This study constructs a rabbit developmental atlas and compares it with mouse data to identify species-specific differences in gene regulation and extra-embryonic tissues.

Climate and mountains shaped human ancestral genetic lineages

This paper models the impact of climate and terrain on human ancestral genetic lineages, showing that these factors explain lineage divergence and migration patterns.

Coordinated Changes in Gene Expression Kinetics Underlie both Mouse and Human Erythroid Maturation

The paper identifies coordinated step-changes in gene expression kinetics during erythropoiesis in both mouse and human, challenging assumptions of RNA velocity analysis.