Fernando J. Calero‐Nieto

This study creates a mouse model of myeloid neoplasm with spontaneous RTK-RAS mutations, showing a premalignant phase and lineage restriction in tumors.

The paper identifies two bone marrow compartments and shows inflammation affects them differently, with type I interferon causing changes in mesenchymal stromal cells.

The paper uses scRNA-Seq and computational methods to predict and validate differentiation trajectories during early mammalian organogenesis, showing agreement between computational predictions and experimental outcomes.

This study constructs a rabbit developmental atlas and compares it with mouse data to identify species-specific differences in gene regulation and extra-embryonic tissues.

The paper develops GASPACHO to identify dynamic eQTLs in antiviral responses using single-cell RNA-seq, uncovering thousands of eQTLs and linking them to disease risk loci.

The paper identifies NOTCH1-JAG1 cis interactions regulated by RADICAL FRINGE that maintain hematopoietic stem cell fate during development.

The paper shows that Dll4 inhibits cell recruitment into aortic clusters, reducing hematopoietic stem cell formation.

This study evaluates spike-in normalization in single-cell RNA sequencing, finding it reliable despite technical noise and minor variance in spike-in RNA addition and behavior.