Jacob E. Friedman

This study shows maternal obesity reduces offspring lifespan in mice, linked to early developmental fibrotic changes across multiple organs.

This study shows that maternal Western-style diet during pregnancy and lactation alters immune and endothelial cell function in juvenile nonhuman primate offspring livers, promoting immune tolerance and fibrosis.

This study shows that a Western diet in pregnant baboons alters the maternal microbiome and miRNA expression in placenta and fetal liver, potentially contributing to NAFLD and metabolic disease risk in offspring.