Arlan G Richardson

The paper shows that cell identity and regulatory logic are preserved during brain aging, but cell-type-specific changes occur in DNA modifications and gene expression.

This study shows that mTOR inhibition restores RNA-regulatory proteins in AD models, suggesting a reversible mTOR-dependent RNA regulatory program in cerebrovascular dysfunction.

This study shows that MPST is essential for maintaining mitochondrial metabolic integrity in neonatal airway epithelial cells, and its loss under hyperoxia disrupts epithelial differentiation and contributes to airway injury.

This study shows maternal obesity reduces offspring lifespan in mice, linked to early developmental fibrotic changes across multiple organs.

This study shows that sex and mitochondrial-haplotype influence age-related changes in gut microbiome composition and metabolites in rats.

This study reevaluates the effect of dietary restriction on four recombinant inbred mouse lines, finding that DR increased lifespan in some lines but had little or negative effects in others.

This study shows that litter expansion in mice leads to long-term metabolic changes that are sex-dependent, with males showing more pronounced effects than females.

This study shows that necroptosis increases with age in the brain and contributes to age-related neuroinflammation in mice.

This study shows that calorie restriction in mice increases microbial diversity and prevents age-related microbiome changes, maintaining a younger microbial and metabolite profile.

The paper introduces a NuTRAP method to isolate RNA and DNA from specific CNS cell types, revealing cell type-specific epigenetic and transcriptomic differences in microglia and astrocytes.

This study shows that caloric restriction reduces age-related DNA methylation changes in the hippocampus of mice, including both CG and non-CG sites, and introduces CR-specific methylation patterns linked to gene expression changes.

This study identifies sexually divergent DNA methylation changes in mouse and human hippocampus with aging, revealing sex as a key factor in epigenomic aging.