Archana Unnikrishnan

This study identifies a ciliary gene program linked to cognitive resilience in mice, independent of age, by integrating behavioral data with transcriptomic profiling.

This study shows maternal obesity reduces offspring lifespan in mice, linked to early developmental fibrotic changes across multiple organs.

This study shows that sex and mitochondrial-haplotype influence age-related changes in gut microbiome composition and metabolites in rats.

This study shows that late-life short-term dietary restriction improves intestinal stem cell function and alters DNA methylation in aged mice.

This study reevaluates the effect of dietary restriction on four recombinant inbred mouse lines, finding that DR increased lifespan in some lines but had little or negative effects in others.

This study shows that litter expansion in mice leads to long-term metabolic changes that are sex-dependent, with males showing more pronounced effects than females.

This study shows that calorie restriction in mice increases microbial diversity and prevents age-related microbiome changes, maintaining a younger microbial and metabolite profile.

This study shows that caloric restriction reduces age-related DNA methylation changes in the hippocampus of mice, including both CG and non-CG sites, and introduces CR-specific methylation patterns linked to gene expression changes.

This study identifies sexually divergent DNA methylation changes in mouse and human hippocampus with aging, revealing sex as a key factor in epigenomic aging.