Scott W. Trappe

In 174 sedentary adults, resistance exercise changed more muscle molecular features than endurance exercise across omes and time points; network analysis nominates MEF2A and NFIC as regulatory hubs.

The paper presents initial findings from the MoTrPAC consortium, showing that acute and chronic exercise induce distinct physiological and molecular responses, with chronic training improving key health metrics.

The paper analyzes multi-omic, multi-tissue molecular responses to acute exercise in sedentary adults, identifying key pathways and exerkines involved in exercise effects.

The paper profiles multi-omic changes in abdominal subcutaneous adipose tissue after acute exercise in sedentary adults, identifying distinct molecular programs and candidate exerkines.

This study examines how acute endurance and resistance exercise alter alternative splicing in human skeletal muscle, adipose tissue, and blood, identifying 5102 differential splicing events and their regulatory mechanisms.

The paper uses single-nucleus multiome sequencing to analyze gene regulatory changes in human skeletal muscle after endurance exercise, identifying fiber-type specific regulatory programs and transcription factor networks.